The Effect of L-Carnitine on Preeclampsia Effected Woman

Pre-eclampsia is a potentially dangerous pregnancy complication characterized by high blood pressure.

Pre-eclampsia usually begins after 20 weeks of pregnancy in a woman whose blood pressure had been normal. It can lead to serious, even fatal, complications for both mother and baby.

There may be no symptoms. High blood pressure and protein in the urine are key features. There may also be swelling in the legs and water retention, but this can be hard to distinguish from normal pregnancy.

Pre-eclampsia can often be managed with oral or IV medication until the baby is sufficiently mature to be delivered. This often requires weighing the risks of early delivery versus the risks of continued pre-eclampsia symptoms.

Ages affected

0-2	Never
3-5	Never
6-13	Very rare
14-18	Common
19-40	Common
41-60	Rare
60+	Never 0

Who Is at Risk for Preeclampsia?

Preeclampsia is most often seen in first-time pregnancies, in pregnant teens, and in women over 40. While it is defined as occurring in women have never had high blood pressure before, other risk factors include:

• A history of high blood pressure prior to pregnancy
• A history of preeclampsia
• Having a mother or sister who had preeclampsia
• A history of obesity
• Carrying more than one baby
• History of diabetes, kidney disease, lupus, or rheumatoid arthritis

Signs & Symptoms of Preeclampsia:

Pregnancy is a confusing time. Your body is going through a lot of changes and it can be hard to tell what's normal and what's a red flag. Learning more about the signs and symptoms of preeclampsia, HELLP syndrome and other hypertensive disorders of pregnancy can help you identify a problem early and ensure the best possible outcome.

Some characteristics of preeclampsia are signs that can be measured, but may not be apparent to you, such as high blood pressure. A symptom is something you may experience and recognize, such as a headache or loss of vision.

No Symptoms

Preeclampsia is a serious condition of pregnancy, and can be particularly dangerous because many of the signs are silent while some symptoms resemble “normal” effects of pregnancy on your body. Many women suffering from preeclampsia don’t feel sick, and may be surprised or become frustrated when they are admitted to the hospital or prescribed bed rest since they still feel well.

High blood pressure (Hypertension)

High blood pressure during pregnancy is one of the biggest red flags that preeclampsia may be developing. And even if it's not a symptom of preeclampsia, it can still be a sign of a problem.

High blood pressure is traditionally defined as blood pressure of 140/90 or greater, measured on two separate occasions six hours apart. During pregnancy, a rise in the lower number (diastolic) of 15 degrees or more, or a rise in the upper number (systolic) of 30 degrees or more can also be a cause for concern.

Protein in your urine (Proteinuria)

Proteinuria, another sign of preeclampsia, is the result of proteins, normally confined to the blood by the filtering role of your kidney, spilling into your urine. This is because preeclampsia temporarily damages this “filter.”  Albumin, as well as many other proteins, are lost this way.

Swelling (Edema)

A certain amount of swelling is normal during pregnancy. Unless you're one of a lucky few, you may notice a little extra puffiness in your feet (good luck fitting into your pre-pregnancy shoes!). 

Headaches

Dull or severe, throbbing headaches, often described as migraine-like that just won't go away are cause for concern.

Nausea or Vomiting

Nausea or vomiting is particularly significant when the onset is sudden and after mid-pregnancy. “Morning sickness” should disappear after the first trimester and the sudden appearance of nausea and vomiting after mid pregnancy may be linked to preeclampsia.

Abdominal (stomach area) and/or Shoulder Pain

This type of abdominal pain, often called epigastric pain or upper right quadrant (URQ) pain, is usually under the ribs on the right side. It can be confused with heartburn, gallbladder problems, flu, indigestion or pain from the baby kicking. Shoulder pain is often called “referred pain” because it radiates from the liver under the right ribs. Lower back pain is different from muscle strain common to pregnancy, because it is usually more acute and specific. Shoulder pain can feel like someone is deeply pinching you along the bra strap or on your neck, or it can be painful to lie on your right side. All of these pain symptoms may be a sign of

Some Other Symptoms are:

• Lower Back Pain
• Sudden Weight Gain
• Changes in Vision
• Hyperreflexia
• Shortness of breath, anxiety

L-Carnitine in Preeclampsia

L-carnitine helps reduce oxidative stress and is used by your body as it turns fat into energy. It's found naturally in your body, in dairy products and in red meat as well as in supplement form. You may hear that supplemental L-carnitine will help you get pregnant, improve your energy while you are pregnant and help your baby gain weight.

Preeclampsia is associated with abnormal lipid metabolism, including fatty acid metabolism. Carnitine plays an indispensable role in the oxidation of fatty acids.

The considerable increased plasma carnitine concentrations, together with the accumulation of lipids, support the role of abnormal lipid metabolism in the pathophysiology of preeclampsia. It is suggested that toxic metabolites resulting from abnormal fatty acid oxidation in the placenta contribute to the endothelial dysfunction of preeclampsia.

Vitamin E in Preeclampsia

The findings indicate that routine supplementation with vitamin E in combination with other supplements during pregnancy did improve outcomes for babies or women. There was a reduction in the number of placentas coming away early (placental abruption) in women given vitamin E supplements in combination with other agents, which was rated as high-quality evidence. 

Crt-E as a Savior in Treatment of Preeclampsia

Crt-E offers Preventive Approach for Preeclampsia enhancement of Body Activity and Conversion of Excess Protein into Body Fuel.

Crt-E offers an ideal mixture of L-Carnitine and Vitamin E which are indispensable in treatment of Preeclampsia.

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HAPPY READING..

- P.A.I.D, (Patient Awareness Initiative Department) Quest Biotech India Pvt. Ltd.

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